您现在的位置是: 首页 > 学校概况 > 机构设置 > 学院设置 > 生命学院 > 生物工程系

生物工程系教师简介 —— 黄渊余 副研究员 / 博士生导师

编辑: 刘惠康

 

 

1、姓名:黄渊余;学位:博士学位;职称:副研究员(博士生导师)

 

2、联系方式:

地址:北京市海淀区中关村南大街5号北京理工大学前沿交叉科学研究院、生命学院

邮编:100081

电话:(010-68911089

电子邮件:yyhuang@bit.edu.cn

 

3、个人简历

2016.07至今     北京理工大学前沿交叉科学研究院、生命学院,副研究员,博士生导师,课题组长(PI

2013.06-2016.06 在北京大学分子医学研究所开展博士后研究

2008.09-2013.06 在北京大学学习并获得理学博士学位

2004.09-2008.07 在中南大学学习并获得理学学士学位

 

4、社会兼职

受邀为Biomaterials (IF=8.387)ACS Appl Mater Interfaces (IF=7.145)Bioconjugate Chem (IF=4.500)Biomater Sci. (IF=3.614)RSC Advances (IF=3.289)J Drug TargetIF=2.821)等SCI重要学术期刊的审稿专家。

 

5、研究领域/方向

核酸(小干扰RNAsiRNA)药物分子体内外递送系统的设计与研究;小核酸药物设计与理性化修饰策略研究;siRNA/核酸药物的药代动力学、药理、毒理研究;以及RNA干扰、CRISPR/Cas9技术相关的基础与应用研究。

 

6、招生专业

学术型硕士生专业:生物医学工程、生物学、化学工程与技术

专业型硕士专业:生物医学工程、生物工程

博士生专业:生物医学工程

 

7、学术成果

RNA干扰(RNAi)是获得诺贝尔生理或医学奖的重要发现,但siRNA的技术应用与药物开发仍面临如何实现高效安全的体内递送、如何显著提升其稳定性与活性等关键科学问题。本人围绕siRNA:(1)从生物、材料化学、物理多角度,设计与研究了多种体内外递送载体,探究其“结构-活性”关系,研究其递送效率、机制与效果,获得了优秀的肝靶向脂质体递送体系,基于该体系,进而开展了多个siRNA药物的临床前药效药理研究工作;(2)研究siRNA的药代动力学特征,首次发现与鉴定了一条新的siRNA体内代谢清除路径,并证明系统给药的siRNA大量、长时间滞留于多个腺体组织,为siRNA药剂的设计与研发提供理论指导;(3)深入解析了siRNA降解机制,提出了理性化的siRNA稳定化修饰策略,并已实际应用到siRNA药物研发中;(4)立足于转化医学研究,参与了中国第一个小核酸药物的IND申报工作,并于201512月获得临床试验批件。

相关成果已在Nano LettAngew Chem Int Ed EnglACS NanoBiomaterialsMol TherTheranostics等期刊杂志发表SCI论文30篇,累计影响因子>220,论文总被引900余次,申请专利3项。第一/通讯作者16篇,平均影响因子>7。(截至20174月)

主持承担国家自然科学基金青年基金1项、博士后科学基金特别资助1项、博士后科学基金面上项目一等资助1项;作为参与人参与国家重大新药创制、863等重大研究课题多项。获得教育部博士研究生学术新人奖,教育部博士研究生国家奖学金,北京大学优秀博士后、“学术十杰”等奖项或荣誉。

 

已发表论文:

a)第一或通讯作者期刊论文:(1: 第一作者, *: 通讯作者,IF2016年公布数据)

1. Zhou J, Wu Y, Wang C, Cheng Q, Han S, Wang X, Zhang J, Deng L, Zhao D, Du L, Cao H, Liang Z, Huang Y*, Dong A*. pH-Sensitive Nanomicelles for High-Efficiency siRNA Delivery in Vitro and in Vivo: An Insight into the Design of Polycations with Robust Cytosolic Release. Nano Lett. 2016 Oct 9. 16 (11): 6916–23. (IF= 13.779JCR1)

2. Guo S1, Huang Y1, Jiang Q, Sun Y, Deng L, Liang Z, Du Q, Xing J, Zhao Y, Wang PC, Dong A, Liang XJ*. Enhanced gene delivery and siRNA silencing by gold nanoparticles coated with charge-reversal polyelectrolyte. ACS Nano. 2010 Sep 28. 4(9):5505-11. (IF = 13.334JCR1区,ESI高被引论文)

3. Huang Y, Hong J, Zheng S, Ding Y, Guo S, Zhang H, Zhang X, Du Q*, Liang Z*. Elimination pathways of systemically delivered siRNA. Mol Ther. 2011 Feb;19(2):381-5. (IF=6.938JCR1)

4. Huang Y1, Lin D1, Jiang Q, Zhang W, Guo S, Xiao P, Zheng S, Wang X, Chen H, Zhang HY, Deng L, Xing J, Du Q, Dong A*, Liang Z*. Binary and ternary complexes based on polycaprolactone-graft-poly (N, N-dimethylaminoethyl methacrylate) for targeted siRNA delivery. Biomaterials. 2012 Jun;33(18):4653-64. (IF= 8.387JCR1)

5. Cheng Q1, Huang Y1*, Zheng H, Wei T, Zheng S, Huo S, Wang X, Du Q, Zhang X, Zhang HY, Liang XJ, Wang C, Tang R*, Liang Z*. The effect of guanidinylation of PEGylated poly(2-aminoethyl methacrylate) on the systemic delivery of siRNA. Biomaterials. 2013 Apr;34(12):3120-31. (IF= 8.387JCR1区)

  • Huang Y*, Cheng Q, Ji JL, Zheng S, Du L, Meng L, Wu Y, Zhao D, Wang X, Lai L, Cao H, Xiao K, Gao S, Liang Z*. Pharmacokinetic behaviors of intravenously administered siRNA in glandular tissues. Theranostics. 2016 Jun 18; 6(10): 1528-1541. (IF=8.854JCR1区)

7. Huang Y*, Wang X, Huang W, Cheng Q, Zheng S, Guo S, Cao H, Liang XJ, Du Q*, Liang Z*. Systemic Administration of siRNA via cRGD-containing Peptide. Sci Rep. 2015 Aug 24;5:12458. (IF= 5.228JCR1区)

  • Huang Y*, Cheng Q, Jin, X, Ji JL, Guo S, Zheng S, Wang X, Cao H, Gao S, Liang XJ, Du Q*, Liang Z*. Systemic and Tumor-targeted Delivery of siRNA by Cyclic NGR and isoDGR Motif-containing Peptide. Biomater Sci. 2016 Feb 23;4(3):494-510. (IF614JCR2区)
  • Huang Y*. Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics. Mol Ther-Nucl Acids. In Press (IF = 5.048, JCR1)

10. Huang Y*, Liang Z*. Asialoglycoprotein Receptor and Its Application in Liver-targeted Drug Delivery. Prog Biochem Biophys. 2015 Jun; 42(6): 501-10. (IF= 0.224JCR4区)

11. Lin D1, Huang Y1, Jiang Q, Zhang W, Yue X, Guo S, Xiao P, Du Q, Xing J, Deng L,  Liang Z*, Dong A*. Structural contributions of blocked or grafted poly(2-dimethylaminoethyl methacrylate) on PEGylated polycaprolactone nanoparticles in siRNA delivery. Biomaterials. 2011 Nov;32(33):8730-42. (IF= 8.387JCR1)

12. Guo S1, Huang Y1, Zhang W, Wang W, Wei T, Lin D, Xing J, Deng L, Du Q, Liang Z*, Liang XJ*, Dong A*. Ternary complexes of amphiphilic polycaprolactone-graft-poly (N,N-dimethylaminoethyl methacrylate), DNA and polyglutamic acid-graft-poly(ethylene glycol) for gene delivery. Biomaterials. 2011 Jun;32(18):4283-92. (IF= 8.387JCR1)

13. Wei Z1, Huang Y1, Zhao D, Hu Z*, Li Z*, Liang Z*. A pliable electroporation patch (ep-Patch) for efficient delivery of nucleic acid molecules into animal tissues with irregular surface shapes. Sci Rep. 2015 Jan 5;5:7618. (IF=5.228JCR1)

 

b)第一或通讯作者SCI/EI收录的会议论文:1: 第一作者, *: 通讯作者, IF2016年公布数据)

14. Huang Y*, Du Q, Liang Z. Systemic and tumor-targeted delivery of siRNA by cyclic NGR motif-containing peptide. Nanomed-Nanotechnol. 2016 Feb;12(2):560. (IF=5.671, JCR1)

15. Huang Y*, Jin X, Zheng S, Gao S*, Liang Z. siRNA mediated inhibition of pancreatic tumor growth in vitro and in vivo. J Control Release. Accept. (IF=7.441, JCR1)

16. Huang Y*, Liang Z. Pharmacokinetic Profiles of Naked and Nano-formulated siRNAs in Glandular Tissues. Nanomed-Nanotechnol. Accept. (IF=5.671, JCR1)

17. Wei Z1, Huang Y1, Zhao D, Liang Z, Li Z*. A parylene-based flexible electroporation chip applicable for in vivo gene and siRNA delivery. In: TRANSDUCERS 2011-2011 16th International Solid-State Sensors, Actuators Microsystems Conf, 2011.06.05-09, vol 2: p 1942-1945. Beijing, China, 2011, Oral Presentation. (EI索引, 被引6)

 

c)共同作者期刊论文:*: 通讯作者,IF2016年公布数据)

  • Liu J, Wei T, Zhao J, Huang Y, Deng H, Kumar A, Wang C, Liang Z, Ma X, Liang XJ*. Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance. Biomaterials. 2016 Mar 10;91:44-56. (IF= 8.387JCR1)
  • Cheng Q1*, Du L1, Meng L, Han S, Wei T, Wang X, Wu Y, Zhou J, Zheng S, Huang Y, Liang X-J, Cao H, Dong A, Liang Z. The promising nanocarrier for doxorubicin and siRNA co-delivery by PDMAEMA based amphiphilic nanomicelles. ACS Appl Mater Interfaces. 2016 Feb 24;8(7):4347-56. (IF=7.145JCR1区,senior author)

20. Han S, Cheng Q, Wu Y, Zhou J, Long X, Wei T, Huang Y, Zheng S, Zhang J, Deng L, Wang X, Liang XJ, Cao H, Liang Z*, Dong A*. Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery. Biomaterials. 2015 Apr;48:45-55. (IF= 8.387JCR1)

21. Liu X, Zhou J, Yu T, Chen C, Cheng Q, Sengupta K, Huang Y, Li H, Liu C, Wang Y, Posocco P, Wang M, Cui Q, Giorgio S, Fermeglia M, Qu F, Pricl S, Shi Y, Liang Z, Rocchi P, Rossi J, Peng L*. Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems. Angew Chem Int Ed Engl. 2014 Oct 27;53(44):11822-7. (IF= 11.709JCR1)

22. Li Y1, Cheng Q1, Jiang Q, Huang Y, Liu H, Zhao Y, Cao W, Ma G, Dai F*, Liang X*, Liang Z*, Zhang X*. Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA. J Control Release. 2014 Feb 28;176:104-14. (IF= 7.441JCR1)

23. Sun Y1, Cao W1, Li S, Jin S, Hu K, Hu L, Huang Y, Gao X, Wu Y, Liang XJ*. Ultrabright and multicolorful fluorescence of amphiphilic polyethyleneimine polymer dots for efficiently combined imaging and therapy. Sci Rep. 2013 Oct 24;3:3036. (IF=5.228JCR1)

24. Wei T1, Liu J1, Ma H, Cheng Q, Huang Y, Zhao J, Huo S, Xue X, Liang Z, Liang XJ*. Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo. Nano Lett. 2013 Jun 12;13(6):2528-34. (IF= 13.779JCR1)

25. Lin D1, Jiang Q1, Cheng Q, Huang Y, Huang P, Han S, Guo S, Liang Z*, Dong A*. Polycation-detachable nanoparticles self-assembled from mPEG-PCL-g-SS-PDMAEMA for in vitro and in vivo siRNA delivery. Acta Biomater. 2013 Aug;9(8):7746-57. (IF= 6.008JCR1)

26. Lin D1, Cheng Q1, Jiang Q, Huang Y, Yang Z, Han S, Zhao Y, Guo S, Liang Z*, Dong A*. Intracellular cleavable poly(2-dimethylaminoethyl methacrylate) functionalized mesoporous silica nanoparticles for efficient siRNA delivery in vitro and in vivo. Nanoscale. 2013 May 21;5(10):4291-301. (IF= 7.760JCR1)

27. Zhou J, Neff CP, Liu X, Zhang J, Li H, Smith DD, Swiderski P, Aboellail T, Huang Y, Du Q, Liang Z, Peng L, Akkina R, Rossi JJ*. Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice. Mol Ther. 2011 Dec;19(12):2228-38. (IF= 6.938JCR1)

28. Guo S, Huang Y, Wei T, Zhang W, Wang W, Lin D, Zhang X, Kumar A, Du Q, Xing J, Deng L, Liang Z, Wang PC, Dong A*, Liang XJ*. Amphiphilic and biodegradable methoxy polyethylene glycol-block-(polycaprolactone-graft-poly(2-(dimethylamino)ethyl methacrylate)) as an effective gene carrier. Biomaterials. 2011 Jan;32(3):879-89. (IF= 8.387JCR1)

29. Huang H1, Wei Z1, Huang Y, Zhao D, Zheng L, Cai T, Wu M, Wang W, Ding X, Zhou Z, Du Q*, Li Z*, Liang Z*. An efficient and high-throughput electroporation microchip applicable for siRNA delivery. Lab Chip. 2011 Jan 7;11(1):163-72. (IF= 5.586JCR1)

30. Hong J, Huang Y, Li J, Yi F, Zheng J, Huang H, Wei N, Shan Y, An M, Zhang H,  Ji J, Zhang P, Xi Z, Du Q*, Liang Z*. Comprehensive analysis of sequence-specific stability of siRNA. FASEB J. 2010 Dec. 24(12):4844-55. (IF= 5.229JCR1)

31. Xiong J1, Yu D1, Wei N, Fu H, Cai T, Huang Y, Wu C, Zheng X, Du Q, Lin D*, Liang Z*. An estrogen receptor alpha suppressor, microRNA-22, is downregulated in estrogen receptor alpha-positive human breast cancer cell lines and clinical samples. FEBS J. 2010 Apr. 277(7):1684-94. (IF= 4.237JCR2)

 

授权和申请专利:

1. 李志宏;梁子才;杜权;魏泽文;黄渊余. 一种用于向活体组织中的细胞内部输运核酸的柔性电极芯片. 申请号:201110150176.1;公开号:CN102367414B.

2. 张鸿雁;高山;黄渊余. 一种siRNA、含有该siRNA的药物组合物和缀合物及它们的应用. 申请号:201510364229.8.

3. 张鸿雁;高山;黄渊余.一种小干扰核酸和药物组合物及其用途. 申请号:201510551827. 6.


(审核:刘晓俏)